The Akyemansa District recorded a total population of 97,374 during the 2010 population and housing census. The population of the district constitutes 3.7 percent of the total population of the Eastern Region. With an annual growth of 2.52% during the 2010 PHC.

The district total projected population for 2017 is 116,158, with projected females (50.7%) and males (49.3%). The District is predominantly rural (65.1%) while urban localities constitute (34.9%). This implies that out of every 10 people in Akyemansa, close to seven people reside in rural areas whilst three reside in the urban areas. The projected population for 2017, computed from the 2010 PHC, further indicates that about 52.0 percent of female reside in the urban areas compare to 48.0 of male with equal proportions (52%) of both sexes are in the rural localities.

With an assumption of same sex ratio from 2010 PHC, the sex ratio for the district is 97.2 males per 100 females. The urban localities have a sex ratio of 92.2 males per 100 females while the rural localities have a sex ratio of 100, which means that for every one male, there is equally one female. The district has five main settlements, which has attained urban status namely Ofoase, Ayirebi, Abenase, Bontodiasae and Adjobue.

There are three Traditional Areas in the District. These are Akyem Kotoku, Akyem Abuakwa and Akyem Bosome. The predominant among them is the Kotoku Traditional Authority, which consists over 85% of the people. It has its traditional headquarters at Akim Oda. The Abuakwa towns are Chia, Adubiase and Odumase whilst Ofoase, Brenase and Anyinase constitute the Bosome towns in the district.

Apart from these indigenous people there are a large number of settlers in the District. These include Asantes, Kwahus, Ga-Adangbes, Ewes, Akuapems and Fantes. The traditional rulers work hand in hand with the District Assembly, attending meetings and workshops to share ideas and offer solutions to the challenges the district confronts with.

The contribution of the Traditional Authorities is enormous in the governance of the district, in that, it promotes peace and unity amongst the people to create an enabling environment where sustainable socio-economic development can thrive.

The district is dominated by the agricultural sector. This sector employs about 73.5 percent of the working population. The proportion engaged in agriculture is high due to the fact that the district has a fertile soil which supports the cultivation of different types of crops, both cash and food crops. Also, the climatic conditions are favourable for crop production. This can also be attributed to the existence of big companies which process agricultural produce, especially palm nuts kernel into oil palm and also the existence of Agricultural Research Institutions both within the district and in adjacent and neighbouring districts. The existence of ready market for oil palm, cocoa and food stuff within and outside the district promotes agricultural activities in the district. The proportion of the active labour force engaged in the other sectors is indicated in table below:

The economic activities carried out in the district include primary (crops) production, animal husbandry, small scale industrial activities, small scale mining and commerce. The Akyemansa District is predominantly an agrarian district as about 73.5 percent of the entire labour force is into agricultural and its related activities. The population in commerce and services forms about 15.2 percent and 3.8 percent of the labour force respectively.